Methionine cycle in nonalcoholic fatty liver disease and its potential applications

Haoyu Wang; Yanwei Wu; Wei Tang

doi:10.1016/j.bcp.2022.115033

Methionine cycle in nonalcoholic fatty liver disease and its potential applications

Biochem Pharmacol. 2022 Jun:200:115033. doi: 10.1016/j.bcp.2022.115033. Epub 2022 Apr 5.

Authors

Haoyu Wang¹, Yanwei Wu², Wei Tang³

Affiliations

¹ University of Chinese Academy of Sciences, Beijing 100049, PR China; Laboratory of Anti-inflammation and Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China. Electronic address: s19-wanghaoyu@simm.ac.cn.
² Laboratory of Anti-inflammation and Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China. Electronic address: wuyanwei@simm.ac.cn.
³ University of Chinese Academy of Sciences, Beijing 100049, PR China; Laboratory of Anti-inflammation and Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China. Electronic address: tangwei@simm.ac.cn.

PMID: 35395242
DOI: 10.1016/j.bcp.2022.115033

Abstract

As a chronic metabolic disease affecting epidemic proportions worldwide, the pathogenesis of Nonalcoholic Fatty Liver Disease (NAFLD) is not clear yet. There is also a lack of precise biomarkers and specific medicine for the diagnosis and treatment of NAFLD. Methionine metabolic cycle, which is critical for the maintaining of cellular methylation and redox state, is involved in the pathophysiology of NAFLD. However, the molecular basis and mechanism of methionine metabolism in NAFLD are not completely understood. Here, we mainly focus on specific enzymes that participates in methionine cycle, to reveal their interconnections with NAFLD, in order to recognize the pathogenesis of NAFLD from a new angle and at the same time, explore the clinical characteristics and therapeutic strategies.

Keywords: Methionine Cycle; NAFLD.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers / metabolism
Humans
Liver / metabolism
Methionine / metabolism
Non-alcoholic Fatty Liver Disease* / metabolism
Oxidation-Reduction

Substances

Biomarkers
Methionine