Ambient air pollution and epileptic seizures: A panel study in Australia

Zhuying Chen; Wenhua Yu; Rongbin Xu; Philippa J Karoly; Matias I Maturana; Daniel E Payne; Lyra Li; Ewan S Nurse; Dean R Freestone; Shanshan Li; Anthony N Burkitt; Mark J Cook; Yuming Guo; David B Grayden

doi:10.1111/epi.17253

Ambient air pollution and epileptic seizures: A panel study in Australia

Epilepsia. 2022 Jul;63(7):1682-1692. doi: 10.1111/epi.17253. Epub 2022 Apr 26.

Authors

Zhuying Chen^{1

2}, Wenhua Yu³, Rongbin Xu³, Philippa J Karoly^{1

4}, Matias I Maturana^{2

5}, Daniel E Payne^{1

2

5}, Lyra Li⁴, Ewan S Nurse^{2

5}, Dean R Freestone⁵, Shanshan Li³, Anthony N Burkitt¹, Mark J Cook^{1

2

4}, Yuming Guo³, David B Grayden^{1

2

4}

Affiliations

¹ Department of Biomedical Engineering, The University of Melbourne, Melbourne, Victoria, Australia.
² Department of Medicine, St Vincent's Hospital, The University of Melbourne, Melbourne, Victoria, Australia.
³ School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.
⁴ Graeme Clark Institute, The University of Melbourne, Melbourne, Victoria, Australia.
⁵ Seer Medical, Melbourne, Victoria, Australia.

Abstract

Objective: Emerging evidence has shown that ambient air pollution affects brain health, but little is known about its effect on epileptic seizures. This work aimed to assess the association between daily exposure to ambient air pollution and the risk of epileptic seizures.

Methods: This study used epileptic seizure data from two independent data sources (NeuroVista and Seer App seizure diary). In the NeuroVista data set, 3273 seizures were recorded using intracranial electroencephalography (iEEG) from 15 participants with refractory focal epilepsy in Australia in 2010-2012. In the seizure diary data set, 3419 self-reported seizures were collected through a mobile application from 34 participants with epilepsy in Australia in 2018-2021. Daily average concentrations of carbon monoxide (CO), nitrogen dioxide (NO₂ ), ozone (O₃ ), particulate matter ≤10 μm in diameter (PM₁₀ ), and sulfur dioxide (SO₂ ) were retrieved from the Environment Protection Authority (EPA) based on participants' postcodes. A patient-time-stratified case-crossover design with the conditional Poisson regression model was used to determine the associations between air pollutants and epileptic seizures.

Results: A significant association between CO concentrations and epileptic seizure risks was observed, with an increased seizure risk of 4% (relative risk [RR]: 1.04, 95% confidence interval [CI]: 1.01-1.07) for an interquartile range (IQR) increase of CO concentrations (0.13 parts per million), whereas no significant associations were found for the other four air pollutants in the whole study population. Female participants had a significantly increased risk of seizures when exposed to elevated CO and NO₂ , with RRs of 1.05 (95% CI: 1.01-1.08) and 1.09 (95% CI: 1.01-1.16), respectively. In addition, a significant association was observed between CO and the risk of subclinical seizures (RR: 1.20, 95% CI: 1.12-1.28).

Significance: Daily exposure to elevated CO concentrations may be associated with an increased risk of epileptic seizures, especially for subclinical seizures.

Keywords: Australia; air pollution; case-crossover design; epilepsy; seizures.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Air Pollutants* / adverse effects
Air Pollutants* / analysis
Air Pollution* / adverse effects
Air Pollution* / analysis
Australia / epidemiology
Epilepsies, Partial*
Epilepsy* / chemically induced
Female
Humans
Nitrogen Dioxide / analysis
Seizures / chemically induced
Seizures / etiology

Substances

Air Pollutants
Nitrogen Dioxide