SARS-CoV-2-associated haemorrhagic encephalitis mimicking Herpes encephalitis

J Neurovirol. 2022 Apr;28(2):322-325. doi: 10.1007/s13365-021-01045-0. Epub 2022 Apr 8.

Abstract

Although acute encephalopathy is quite commonly seen in patients of SARS-CoV-2 infection, encephalitis characterised by brain inflammation is relatively rare. Encephalitis caused by Herpes simplex type 1 is the most common cause of identified sporadic encephalitis, and early diagnosis and prompt treatment can prevent the devastating outcome. In this brief communication, we report a case of SARS-CoV-2 associated haemorrhagic encephalitis mimicking herpes encephalitis. In today's pandemic era, it is especially important to distinguish herpes encephalitis from SARS-CoV-2-associated encephalitis as treatment and prognosis of both the conditions differ greatly. This case highlights the importance of suspecting SARS-CoV-2 infection in a patient presenting with clinical symptoms and brain imaging suggestive of Herpes encephalitis.

Keywords: Haemorrhagic encephalitis; Herpes encephalitis; Mimicking; SARS-CoV-2.

Publication types

  • Case Reports

MeSH terms

  • COVID-19* / diagnosis
  • Encephalitis, Herpes Simplex* / diagnosis
  • Encephalitis, Herpes Simplex* / drug therapy
  • Encephalitis, Viral* / diagnosis
  • Encephalitis, Viral* / drug therapy
  • Herpes Simplex*
  • Humans
  • Pandemics
  • SARS-CoV-2