Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity

Bin Tu; Yanrong Gao; Feifei Sun; Mingjie Shi; Yongzhuo Huang

doi:10.3389/fphar.2022.840440

Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity

Front Pharmacol. 2022 Mar 22:13:840440. doi: 10.3389/fphar.2022.840440. eCollection 2022.

Authors

Bin Tu^{1

2}, Yanrong Gao^{1

2}, Feifei Sun^{1

3}, Mingjie Shi¹, Yongzhuo Huang^{1

2

4

5

6}

Affiliations

¹ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
² University of Chinese Academy of Sciences, Beijing, China.
³ School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China.
⁴ Zhongshan Institute for Drug Discovery, SIMM, CAS, Zhongshan, China.
⁵ NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients, Shanghai, China.
⁶ School of Advanced Study, Institute of Natural Medicine and Health Product, Taizhou University, Taizhou, China.

Abstract

The hallmarks of cancer include dysregulated metabolism and immune evasion. As a basic way of metabolism, lipid metabolism is reprogrammed for the rapid energy and nutrient supply in the occurrence and development of tumors. Lipid metabolism alterations that occur in the tumor microenvironment (TME) affect the antitumor responses of immune cells and cause immune evasion. Therefore, targeting lipid metabolism in the TME for enhancing the antitumor effect of immune cells is a promising direction for cancer treatment. Cancer nanomedicine has great potential in regulating tumor metabolism and tumor immunity. This review summarizes the nanotechnology-based strategies for lipid metabolism regulation in the TME for enhanced anticancer immune responses.

Keywords: cancer nanomedicine; lipid metabolism; nanotechnology; tumor immunity; tumor metabolism; tumor microenvironment.

Publication types

Review