Liver steatosis, cardiac and renal fibrosis, and hypertension in overweight rats: Angiotensin-(3-4)-sensitive hepatocardiorenal syndrome

Thuany Crisóstomo; Marco A E Pardal; Simone A Herdy; Humberto Muzi-Filho; Debora B Mello; Christina M Takiya; Rafael Luzes; Adalberto Vieyra

doi:10.1016/j.metop.2022.100176

Liver steatosis, cardiac and renal fibrosis, and hypertension in overweight rats: Angiotensin-(3-4)-sensitive hepatocardiorenal syndrome

Metabol Open. 2022 Mar 18:14:100176. doi: 10.1016/j.metop.2022.100176. eCollection 2022 Jun.

Authors

Thuany Crisóstomo^{1

2}, Marco A E Pardal³, Simone A Herdy⁴, Humberto Muzi-Filho^{2

3}, Debora B Mello², Christina M Takiya³, Rafael Luzes^{3

4}, Adalberto Vieyra^{2

3

4}

Affiliations

¹ Leopoldo de Meis Institute of Medical Biochemistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
² National Center of Structural Biology and Bioimaging/CENABIO, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
³ Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
⁴ Graduate Program in Translational Biomedicine/BIOTRANS, University of Grande Rio, Duque de Caxias, Brazil.

Abstract

Overweight/obesity is a growing pandemic that affects many organs and tissues. We have investigated whether a high-lipid diet provokes an imbalance between type 1 and type 2 angiotensin II (Ang II) receptors signaling, leading to liver alterations associated with cardiovascular and kidney disturbances. Chronic administration of a high-lipid diet can provoke hepatocardiorenal syndrome resulting from activation of the Ang II→type 1 receptor axis, which is entirely counteracted by Ang-(3-4), the allosteric enhancer of the Ang II→type 2 receptor pathway.

Keywords: Arterial hypertension; Cardiac and renal fibrosis; Hepatocardiorenal syndrome; Hyperlipidic diet; Non-alcoholic liver steatosis; Overweight rats.