Engineering organ-on-a-chip systems to model viral infections

Fahimeh Shahabipour; Sandro Satta; Mahboobeh Mahmoodi; Argus Sun; Natan Roberto de Barros; Song Li; Tzung Hsiai; Nureddin Ashammakhi

doi:10.1088/1758-5090/ac6538

Engineering organ-on-a-chip systems to model viral infections

Biofabrication. 2023 Feb 6;15(2):10.1088/1758-5090/ac6538. doi: 10.1088/1758-5090/ac6538.

Authors

Fahimeh Shahabipour^{1

2}, Sandro Satta³, Mahboobeh Mahmoodi^{4

5}, Argus Sun⁴, Natan Roberto de Barros^{3

4}, Song Li⁴, Tzung Hsiai^{6

7}, Nureddin Ashammakhi^{4

8}

Affiliations

¹ Skin Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran.
² Orthopedic Research Center, Mashhad University of Medical Science, Mashhad, Iran.
³ Department of Medicine, School of Medicine, University of California, Los Angeles, CA, United States of America.
⁴ Department of Bioengineering, School of Engineering, University of California, Los Angeles, CA, United States of America.
⁵ Department of Biomedical Engineering, Yazd Branch, Islamic Azad University, Yazd, Iran.
⁶ Division of Cardiology, Department of Medicine, School of Medicine, University of California, Los Angeles, CA, United States of America.
⁷ Greater Los Angeles VA Healthcare System, Los Angeles, CA, United States of America.
⁸ Department of Biomedical Engineering, College of Engineering and Institute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, MI, United States of America.

Abstract

Infectious diseases remain a public healthcare concern worldwide. Amidst the pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 infection, increasing resources have been diverted to investigate therapeutics targeting the COVID-19 spike glycoprotein and to develop various classes of vaccines. Most of the current investigations employ two-dimensional (2D) cell culture and animal models. However, 2D culture negates the multicellular interactions and three-dimensional (3D) microenvironment, and animal models cannot mimic human physiology because of interspecies differences. On the other hand, organ-on-a-chip (OoC) devices introduce a game-changer to model viral infections in human tissues, facilitating high-throughput screening of antiviral therapeutics. In this context, this review provides an overview of thein vitroOoC-based modeling of viral infection, highlighting the strengths and challenges for the future.

Keywords: COVID-19; microfluidic; organ on-a-chip; viral infection.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
COVID-19*
Humans
Microphysiological Systems
Virus Diseases*

Abstract

Publication types

MeSH terms

Grants and funding