Of flies, mice and neural control of food intake: lessons to learn from both models

Abstract

In her book, A Room of One's Own, the famous author Virginia Woolf writes "One cannot think well, love well, sleep well if one has not dined well". This is true. All animals need to forage for food and consume specific nutrients to maintain their physiological homeostasis, maximize their fitness and their reproduction. After decades of research in humans and many model organisms, we now know that our brain is one of the key players that control what, when, and how much we eat. In this review, we discuss the recent literature on neural control of food intake behaviors in mice and flies with the view that these two model organisms complement one another in efforts to uncover conserved principles brains use to regulate energy metabolism and food ingestion.