Fetal Transfer of Human Metapneumovirus-Neutralizing Antibodies Is Reduced From Mothers Living With HIV-1

Lesego M Ramocha; Bernadette G van den Hoogen; Vicky Baillie; Stefan van Nieuwkoop; Clare L Cutland; Stephanie Jones; Andrew Moultrie; Alane Izu; Charl Verwey; Shabir A Madhi; Jeffrey R Dorfman

doi:10.1093/jpids/piac018

Fetal Transfer of Human Metapneumovirus-Neutralizing Antibodies Is Reduced From Mothers Living With HIV-1

J Pediatric Infect Dis Soc. 2022 Jul 21;11(7):341-344. doi: 10.1093/jpids/piac018.

Authors

Lesego M Ramocha^{1

2}, Bernadette G van den Hoogen³, Vicky Baillie^{1

2

4}, Stefan van Nieuwkoop³, Clare L Cutland⁴, Stephanie Jones^{1

2}, Andrew Moultrie^{1

2}, Alane Izu^{1

2

4}, Charl Verwey^{1

5}, Shabir A Madhi^{1

2

4}, Jeffrey R Dorfman^{1

2

4

6}

Affiliations

¹ South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
² Department of Science/National Research Foundation: Vaccine Preventable Diseases, University of the Witwatersrand, Faculty of Health Science, Johannesburg, South Africa.
³ Department of Viroscience, Erasmus University Medical Centre, Rotterdam, the Netherlands.
⁴ African Leadership in Vaccinology Expertise (ALIVE), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
⁵ Department of Pediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
⁶ Division of Medical Virology, Department of Pathology, Stellenbosch University, Cape Town, South Africa.

PMID: 35390156
DOI: 10.1093/jpids/piac018

Abstract

Transplacental hMPV-neutralizing antibody transfer was reduced from mothers living with HIV-1. However, a comparison of antibody titers at birth between hMPV hospitalization cases at <6 months and matched controls suggested that reduced maternal antibody might not be the primary cause of the previously reported elevated hMPV risk in HIV-1-exposed infants.

Keywords: HIV-1; HIV-1 exposure; antibody transfer; human metapneumovirus; neutralizing antibodies.

© The Author(s) 2022. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

MeSH terms

Antibodies, Neutralizing
Antibodies, Viral
HIV-1*
Humans
Infant, Newborn
Metapneumovirus*
Paramyxoviridae Infections*

Substances

Antibodies, Neutralizing
Antibodies, Viral

Abstract

MeSH terms

Substances

Grants and funding