Choroidal vascularity index change in macular telangiectasia type 2

Heejeong Chun; Hyun Suh; Joo Young Kim; Jae Hyuck Kwak; Rae Young Kim; Mirinae Kim; Young-Gun Park; Young-Hoon Park

doi:10.1371/journal.pone.0262112

Choroidal vascularity index change in macular telangiectasia type 2

PLoS One. 2022 Apr 7;17(4):e0262112. doi: 10.1371/journal.pone.0262112. eCollection 2022.

Authors

Heejeong Chun^{1

2}, Hyun Suh¹, Joo Young Kim^{1

2}, Jae Hyuck Kwak^{1

2}, Rae Young Kim^{1

2}, Mirinae Kim^{1

2}, Young-Gun Park^{1

2}, Young-Hoon Park^{1

2}

Affiliations

¹ Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
² Catholic Institute for Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Abstract

Purpose: To analyze choroidal structure using subfoveal choroidal thickness (SFCT) and choroidal vascularity index (CVI) in Macular Telangiectasia (MacTel) type 2.

Methods: Medical records of 43 eyes with MacTel type 2 and 30 sex and age-matched healthy eyes were retrospectively reviewed. Their SFCT and CVI were measured using the SS-OCT scan passing through the central fovea and image binarization. The difference in baseline SFCT and CVI from each group and their yearly changes up to second year of follow up were analyzed. The baseline characteristics of the groups were also compared.

Results: The baseline characteristics, including CVI and SFCT, of the MacTel group and the control group were not significantly different, except for BCVA. The mean CVI of MacTel group were 64.59 ± 2.92%, 63.76 ± 2.67%, and 62.97 ± 2.74% (p < 0.001) whereas that of control group were 63.33 ± 2.45%, 63.04 ± 2.46%, and 63.43 ± 2.25% (p = 0.636) at baseline, 1 and 2 years, respectively. The mean SFCT of MacTel group were 324.65 ± 89.65μm, 326.14 ± 93.11μm, and 322.65 ± 91.77μm (p = 0.436), whereas that of control group were 304.30 ± 51.86 μm, 300.86 ± 52.64μm, and 298.55 ± 53.71μm (p = 0.275) at baseline, 1 and 2 years, respectively.

Conclusion: CVI decreases at a faster rate in MacTel type 2 in comparison with healthy subjects. This may suggest possible choroidal involvement in the progression of MacTel type 2.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Choroid / diagnostic imaging
Diabetic Retinopathy*
Humans
Retinal Telangiectasis* / diagnostic imaging
Retrospective Studies
Tomography, Optical Coherence / methods

Supplementary concepts

Idiopathic Juxtafoveal Retinal Telangiectasia

Grants and funding

This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF-2020R1F1A1074898). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.