A covalent organic framework with a self-contained light source for photodynamic therapy

Wen-Xiu Ren; Fei Kong; Yu-Qing Shao; Qing-Yun Huang; Long-Fei Sun; Jie Feng; Yu-Bin Dong

doi:10.1039/d2cc01397e

A covalent organic framework with a self-contained light source for photodynamic therapy

Chem Commun (Camb). 2022 Apr 26;58(34):5245-5248. doi: 10.1039/d2cc01397e.

Authors

Wen-Xiu Ren¹, Fei Kong¹, Yu-Qing Shao¹, Qing-Yun Huang¹, Long-Fei Sun¹, Jie Feng¹, Yu-Bin Dong¹

Affiliation

¹ College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education Shandong Normal University, Jinan 250014, People's Republic of China. Jiefeng@sdnu.edu.cn.

PMID: 35388841
DOI: 10.1039/d2cc01397e

Abstract

External light-independent antitumor PDT is successfully realized with a covalent organic framework (COF)-based host-guest nanosystem. Its highly effective antitumor behavior is fully demonstrated by both H₂O₂-overexpressed 4T1 and H₂O₂-less expressed HCT116 and MCF-7 xenograft models.

MeSH terms

Humans
Hydrogen Peroxide
Metal-Organic Frameworks* / pharmacology
Photochemotherapy*

Substances

Metal-Organic Frameworks
Hydrogen Peroxide