Mental healthcare utilisation by patients before and after receiving paliperidone palmitate treatment: mirror image analyses

BMJ Open. 2022 Apr 6;12(4):e051567. doi: 10.1136/bmjopen-2021-051567.

Abstract

Objectives: To compare mental healthcare use and healthcare professional (HCP) contacts for patients before and after initiation of paliperidone palmitate.

Setting: The South London and Maudsley NHS Foundation Trust (SLAM) Biomedical Research Centre Clinical Record Interactive Search.

Participants: We identified all adults with a diagnosis of schizophrenia (International Classification of Diseases 10th Revision: F20.x), who had received paliperidone palmitate prescription for at least 365 days and had at least 1 year of recorded treatment from SLAM, prior to the first recorded receipt of paliperidone palmitate.

Primary and secondary outcome measures: Inpatient and community mental healthcare service use, such as inpatient bed days, number of active days in the service, face-to-face and telephone HCP use in the 12 months before and after paliperidone palmitate initiation.

Results: We identified 664 patients initiated on paliperidone palmitate. Following initiation, inpatient bed days were lower, although patients remained active on the service case load longer for both mirror approach 1 (mean difference of inpatient bed days -10.48 (95% CI -15.75 to -5.22); days active 40.67 (95% CI 33.39 to 47.95)) and mirror approach 2 (mean difference of inpatient bed days -23.96 (95% CI -30.01 to -17.92); mean difference of days active 40.69 (95% CI 33.39 to 47.94)). The postinitiation period was further characterised by fewer face-to-face and telephone contacts with medical and social work HCPs, and an increased contact with clinical psychologists.

Conclusions: Our findings indicate a change in the profile of HCP use, consistent with a transition from treatment to possible rehabilitation.

Keywords: adult psychiatry; mental health; schizophrenia & psychotic disorders.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antipsychotic Agents* / therapeutic use
  • Humans
  • London
  • Paliperidone Palmitate / therapeutic use
  • Patient Acceptance of Health Care
  • Schizophrenia* / drug therapy

Substances

  • Antipsychotic Agents
  • Paliperidone Palmitate