Pathomechanisms of AERD-Recent Advances

Annina Lyly; Tanya M Laidlaw; Marie Lundberg

doi:10.3389/falgy.2021.734733

Pathomechanisms of AERD-Recent Advances

Front Allergy. 2021 Sep 10:2:734733. doi: 10.3389/falgy.2021.734733. eCollection 2021.

Authors

Annina Lyly^{1

2}, Tanya M Laidlaw³, Marie Lundberg¹

Affiliations

¹ Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
² Inflammation Center, Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
³ Department of Medicine, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.

Abstract

The pathomechanisms behind NSAID-exacerbated respiratory disease are complex and still largely unknown. They are presumed to involve genetic predisposition and environmental triggers that lead to dysregulation of fatty acid and lipid metabolism, altered cellular interactions involving transmetabolism, and continuous and chronic inflammation in the respiratory track. Here, we go through the recent advances on the topic and sum up the current understanding of the background of this illness that broadly effects the patients' lives.

Keywords: CRSwNP; N-ERD; NSAID-exacerbated respiratory disease; aspirin-exacerbated respiratory disease; asthma; chronic rhinosinusitis; nasal polyp; samter's triad.

Publication types

Review