Immunonutrition for Pediatric Patients With Cow's Milk Allergy: How Early Interventions Could Impact Long-Term Outcomes

Laura Carucci; Serena Coppola; Anna Luzzetti; Luana Voto; Veronica Giglio; Lorella Paparo; Rita Nocerino; Roberto Berni Canani

doi:10.3389/falgy.2021.676200

Immunonutrition for Pediatric Patients With Cow's Milk Allergy: How Early Interventions Could Impact Long-Term Outcomes

Front Allergy. 2021 Jul 9:2:676200. doi: 10.3389/falgy.2021.676200. eCollection 2021.

Authors

Laura Carucci^{1

2}, Serena Coppola^{1

2}, Anna Luzzetti^{1

2}, Luana Voto^{1

2}, Veronica Giglio^{1

2}, Lorella Paparo^{1

2}, Rita Nocerino^{1

2}, Roberto Berni Canani^{1

2

3

4}

Affiliations

¹ Department of Translational Medical Science, University of Naples Federico II, Naples, Italy.
² ImmunonutritionLab at the CEINGE Advanced Biotechnologies Research Center, University of Naples Federico II, Naples, Italy.
³ European Laboratory for the Investigation of Food-Induced Diseases, University of Naples Federico II, Naples, Italy.
⁴ Task Force for Microbiome Studies, University of Naples Federico II, Naples, Italy.

Abstract

Cow's milk allergy (CMA) is one of the most common food allergies and one of the main causes of food-induced anaphylaxis in the pediatric age. Moreover, up to 45% of CMA children develop other atopic manifestations later in life, a phenomenon commonly named atopic march. Thus, CMA imposes a significant cost to health care systems as well as to families, and has emerged as one of the most expensive allergic diseases. The immunonutrition strategy builds its foundation on the ability of selected dietary factors to modulate immune system development and function. Recent studies highlighted the potential of immunonutrition in the management of CMA. This review is focused on the mechanisms and long-term clinical outcomes of the immunonutrition approach in children with CMA.

Keywords: atopic march; dietary peptides; food allergy; gut microbiome; immune tolerance.

Publication types

Review