Iron Overload in Chronic Kidney Disease: Less Ferritin, More T2*MRI

Abdulqadir J Nashwan; Mohamed A Yassin; Mohamed Izham Mohamed Ibrahim; Hanan F Abdul Rahim; Mujahed Shraim

doi:10.3389/fmed.2022.865669

Iron Overload in Chronic Kidney Disease: Less Ferritin, More T2^*MRI

Front Med (Lausanne). 2022 Mar 21:9:865669. doi: 10.3389/fmed.2022.865669. eCollection 2022.

Authors

Abdulqadir J Nashwan¹, Mohamed A Yassin², Mohamed Izham Mohamed Ibrahim³, Hanan F Abdul Rahim⁴, Mujahed Shraim⁴

Affiliations

¹ Department of Nursing, Hazm Mebaireek General Hospital, Hamad Medical Corporation, Doha, Qatar.
² Hematology and Oncology, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.
³ College of Pharmacy, QU Health, Qatar University, Doha, Qatar.
⁴ Department of Public Health, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.

Abstract

To date, there is no consensus on the most reliable marker of iron status in patients with chronic kidney disease (CKD). Serum ferritin is used routinely, although it may be a misleading marker for iron overload. The success of T2^* MRI in monitoring iron overload in patients with hemoglobinopathies can be beneficial to monitoring patients with CKD.

Keywords: T2*MRI; chronic kidney disease; iron overload; liver iron concentration (LIC); serum ferritin.

Publication types

Review