Alloyed nanostructures integrated metal-phenolic nanoplatform for synergistic wound disinfection and revascularization

Yi Xie; Shengqiu Chen; Xu Peng; Xiaoling Wang; Zhiwei Wei; Joseph J Richardson; Kang Liang; Hirotaka Ejima; Junling Guo; Changsheng Zhao

doi:10.1016/j.bioactmat.2022.03.004

Alloyed nanostructures integrated metal-phenolic nanoplatform for synergistic wound disinfection and revascularization

Bioact Mater. 2022 Mar 19:16:95-106. doi: 10.1016/j.bioactmat.2022.03.004. eCollection 2022 Oct.

Authors

Yi Xie¹, Shengqiu Chen¹, Xu Peng², Xiaoling Wang³, Zhiwei Wei¹, Joseph J Richardson⁴, Kang Liang⁵, Hirotaka Ejima⁴, Junling Guo^{1

3

6}, Changsheng Zhao^{1

7}

Affiliations

¹ College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, Sichuan, 610065, China.
² Laboratory Animal Center, Sichuan University, Chengdu, Sichuan, 610065, China.
³ BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, Sichuan Univerisity, Chengdu, Sichuan, 610065, China.
⁴ Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
⁵ School of Chemical Engineering, Graduate School of Biomedical Engineering, and Australian Centre for NanoMedicine, University of New South Wales, Sydney, NSW, 2052, Australia.
⁶ Bioproducts Institute, Departments of Chemical and Biological Engineering, The University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.
⁷ School of Chemical Engineering, Sichuan University, Chengdu, Sichuan, 610065, China.

Abstract

New materials for combating bacteria-caused infection and promoting the formation of microvascular networks during wound healing are of vital importance. Although antibiotics can be used to prevent infection, treatments that can disinfect and accelerate wound healing are scarce. Herein, we engineer a coating that is both highly compatible with current wound dressing substrates and capable of simultaneously disinfecting and revascularizing wounds using a metal-phenolic nanoplatform containing an alloyed nanostructured architecture (Ag@Cu-MPN_NC). The alloyed nanostructure is formed by the spontaneous co-reduction and catalytic disproportionation reaction of multiple metal ions on a foundation metal-phenolic supramolecular layer. This synergistic presence of metals greatly improves the antibacterial activity against both Gram-negative and Gram-positive pathogenic bacteria, while demonstrating negligible cytotoxicity to normal tissue. In infected rat models, the Ag@Cu-MPN_NC could kill bacteria efficiently, promoting revascularization and accelerate wound closure with no adverse side effects in infected in vivo models. In other words, this material acts as a combination therapy by inhibiting bacterial invasion and modulating bio-nano interactions in the wound.

Keywords: Antibacterial activity; Metal-phenolic network; Revascularization; Wound healing.