Intracellular Cholesterol Synthesis and Transport

Qingyang Shi; Jiahuan Chen; Xiaodong Zou; Xiaochun Tang

doi:10.3389/fcell.2022.819281

Intracellular Cholesterol Synthesis and Transport

Front Cell Dev Biol. 2022 Mar 21:10:819281. doi: 10.3389/fcell.2022.819281. eCollection 2022.

Authors

Qingyang Shi¹, Jiahuan Chen², Xiaodong Zou², Xiaochun Tang^{2

3}

Affiliations

¹ Center of Reproductive Medicine and Center of Prenatal Diagnosis, The First Hospital, Jilin University, Changchun, China.
² Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University, Changchun, China.
³ Chongqing Research Institute of Jilin University, Chongqing, China.

Abstract

Cholesterol homeostasis is related to multiple diseases in humans, including cardiovascular disease, cancer, and neurodegenerative and hepatic diseases. The cholesterol levels in cells are balanced dynamically by uptake, biosynthesis, transport, distribution, esterification, and export. In this review, we focus on de novo cholesterol synthesis, cholesterol synthesis regulation, and intracellular cholesterol trafficking. In addition, the progression of lipid transfer proteins (LTPs) at multiple contact sites between organelles is considered.

Keywords: cholesterol synthesis; cholesterol trafficking; endoplasmic reticulum; intracellular; sterol regulatory element-binding proteins.

Publication types

Review