Ketones regulate endothelial homeostasis

Gary D Lopaschuk; David A Hess; Subodh Verma

doi:10.1016/j.cmet.2022.03.008

Ketones regulate endothelial homeostasis

Cell Metab. 2022 Apr 5;34(4):513-515. doi: 10.1016/j.cmet.2022.03.008.

Authors

Gary D Lopaschuk¹, David A Hess², Subodh Verma³

Affiliations

¹ Cardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, AB, Canada. Electronic address: gary.lopaschuk@ualberta.ca.
² Robarts Research Institute, University of Western Ontario, London, ON, Canada.
³ Division of Cardiac Surgery, Li Ka Shing Knowledge Institute of St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.

PMID: 35385704
DOI: 10.1016/j.cmet.2022.03.008

Abstract

In a recent paper in EMBO Molecular Medicine, Weis et al. reveal that cardiac endothelial cells can oxidize ketone bodies, which enhances cell proliferation, migration, and vessel sprouting. Furthermore, increasing ketone body levels with a ketogenic diet can increase endothelial cell proliferation and prevent blood vessel rarefication in hypertrophied mouse hearts. This suggests that increasing endothelial cell ketone oxidation has potential in treating heart failure.

Publication types

Comment

MeSH terms

Animals
Diet, Ketogenic*
Endothelial Cells
Heart Failure*
Homeostasis
Ketone Bodies
Ketones / pharmacology
Mice

Substances

Ketone Bodies
Ketones