In dust-generating scenarios in occupational environments, it is important to take measures to prevent not only pneumoconiosis, but also heatstroke. The aim of this study was to verify whether using a tight-fitting half-facepiece breath-response powered air-purifying respirator (PAPR) in combination with a self-produced cooling device could abate the deep body temperature while performing activities. We conducted a crossover study involving 10 subjects. The subjects were subjected to three conditions: wearing a PAPR equipped with a cooling device, PAPR, or a replaceable particulate respirator. During the experiment, the rectal temperature of the subjects was measured, along with the temperature near the PAPR inlet in container with the cooling device when the PAPR equipped with the cooling device was worn. The subjects rested in a cold chamber set at a dry-bulb temperature of 28°C and relative humidity of 45% for 20 min. Then, they moved to a hot chamber set to a dry-bulb temperature of 36°C (with the same relative humidity) in 5 min and exercised on a cycle ergometer for 30 min. After that, the subjects moved to the cold chamber for 5 min and rested for 20 min. Notably, the air inhaled by the subjects wearing PAPR equipped with the cooling device was approximately 10°C cooler than the ambient air. Furthermore, 35 min after the initiation of the experiment (after the middle of the exercise period), the rectal temperature of the participants wearing the PAPR equipped with the cooling device was lower than of those wearing PAPR or replaceable particulate respirators (p <0.05). Thus, we could deduce that the self-produced cooling device was useful in abating deep body temperature. PAPR is useful for its potential applications in hot occupational environments and can save lives in working environments where heat stress can result in major medical complications.