Hemodynamic management of the micropreemie: When inotropes are not enough

Semin Fetal Neonatal Med. 2022 Jun;27(3):101329. doi: 10.1016/j.siny.2022.101329. Epub 2022 Mar 31.

Abstract

Managing perfusion in the micropreemie is challenging and should be guided by the patho-physiology, gestational and postnatal age of the baby, perinatal history, and the persistence of fetal shunts. The assessment should incorporate bedside tools such as blood pressure, clinical perfusion markers, and functional echocardiography. The multimodal approach to diagnose and identify the cause of hemodynamic compromise paves the way to a targeted approach to treatment. Characterizing the predominant pathophysiologic cause of low cardiac output and impaired cellular metabolism enables a more accurate use of inotropes, vasopressors, and volume support to suit a particular pathophysiologic situation.

Keywords: Hypotension; Inotrope; Micropreemie; Perfusion; Preterm.

Publication types

  • Review

MeSH terms

  • Blood Pressure / physiology
  • Cardiotonic Agents* / pharmacology
  • Cardiotonic Agents* / therapeutic use
  • Hemodynamics*
  • Humans
  • Vasoconstrictor Agents / therapeutic use

Substances

  • Cardiotonic Agents
  • Vasoconstrictor Agents