Recent advances in estrogen receptor-targeted probes conjugated to BODIPY dyes

Linlin Gai; Weice Sun

doi:10.1016/j.steroids.2022.109031

Recent advances in estrogen receptor-targeted probes conjugated to BODIPY dyes

Steroids. 2022 Jul:183:109031. doi: 10.1016/j.steroids.2022.109031. Epub 2022 Apr 4.

Authors

Linlin Gai¹, Weice Sun²

Affiliations

¹ Central Laboratory, Weifang People's Hospital, Weifang, Shandong 261041, PR China. Electronic address: gailinlin0504@126.com.
² Vascular Surgery, Weifang Traditional Chinese Hospital, Weifang, Shandong 261041, PR China.

PMID: 35381270
DOI: 10.1016/j.steroids.2022.109031

Abstract

Estrogens, is a class of steroid hormones associated with the occurrence and development of breast cancer, that bind to estrogen receptors (ER). The development of BODIPY-based fluorescent ligands for the ER has continued to gain tremendous attention over the past 20 years. This review focuses on the synthesis methods, optical properties, and biological activity of BODIPY fluorescent probes conjugated to ER ligands. These will provide new strategy for designing fluorescent probes for targeting estrogen receptors.

Keywords: BODIPY; Estrogen receptor; Fluorescent probes; Receptor-binding assay.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Boron Compounds
Fluorescent Dyes*
Humans
Ligands
Receptors, Estrogen* / metabolism

Substances

4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
Boron Compounds
Fluorescent Dyes
Ligands
Receptors, Estrogen