First Data on Antiviral Activity of Aqueous Extracts from Medicinal Mushrooms from the Altai Mountains in Russia against Influenza Virus Type A

Vyacheslav A Vlasenko; Tatyana N Ilyicheva; Ivan V Zmitrovich; Dejidmaa Turmunkh; Budsuren Dondov; Tamara V Teplyakova; Ochirbat Enkhtuya; Kherlenchimeg Nyamsuren; Javkhlan Samiya; Uranchimeg Altangerel; Sergey V Asbaganov; Anastasia V Vlasenko

doi:10.1615/IntJMedMushrooms.2021041541

First Data on Antiviral Activity of Aqueous Extracts from Medicinal Mushrooms from the Altai Mountains in Russia against Influenza Virus Type A

Int J Med Mushrooms. 2021;23(12):37-45. doi: 10.1615/IntJMedMushrooms.2021041541.

Affiliations

¹ Laboratory of Mycology, Algology, and Lichenology, Central Siberian Botanical Garden of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
² Laboratory of the Department of Zoonosis Infections and Influenza, State Research Center of Virology and Biotechnology "Vector," Koltsovo, Novosibirsk Region 630559, Russia.
³ Laboratory of Systematics and Geography of the Fungi, Komarov Botanical Institute, Russian Academy of Sciences, Prof. Popova St. 2, St. Petersburg, 197376, Russia.
⁴ Laboratory of Plant Pathology, Plant Protection Research Institute of Mongolia, Khan-Uul District, Ulaanbaatar 17024, Mongolia.
⁵ Federal State Research Institution, State Research Center of Virology and Biotechnology Vector of the Federal Service for Surveillance in Consumer Rights Protection and Human Wellbeing, Novosibirsk Region, Russia.
⁶ Laboratory of Plant Taxonomy, Institute of Botany, Mongolian Academy of Sciences, Bayanzurkh District, Ulaanbaatar 13330, Mongolia.

PMID: 35381152
DOI: 10.1615/IntJMedMushrooms.2021041541

Abstract

Fungi are a promising source of biologically active compounds. Here we publish new data on the antiviral activity of some Agaricomycetes species. We studied the antiviral activity of the total polysaccharide fraction of aqueous extracts from fruiting bodies of eight Agaricomycetes (Hygrophorus agathosmus, H. quelitii, H. speciosus, Clitocybe nebularis, Lactarius deterrimus [two strains], L. porniniae, Russulapelargonia, and R. xerampelina) collected near Dzhazator, Republic of Altay, Russia (Altai Mountains), against a highly pathogenic strain of influenza virus A/Li-petsk/1V/2018 (H1N1 pdm09) (EPI_ISL_332798). All of the studied extracts from the Hygrophorus spp. fruiting bodies showed an antiviral effect, whereas the extracts from Clitocybe, Lactarius, and Russula spp. fruiting bodies did not show such an effect. This is the first report of antiviral activity of extracts from Hygrophorus spp. fruiting bodies.

MeSH terms

Agaricales*
Antiviral Agents / pharmacology
Influenza A Virus, H1N1 Subtype*
Russia

Substances

Antiviral Agents