Nodular fasciitis of the periorbital soft tissue in an adolescent confirmed by USP6 gene rearrangement

Douglas P Dworak; Amanda C Maltry; W Robert Bell

doi:10.1016/j.ajoc.2022.101496

Nodular fasciitis of the periorbital soft tissue in an adolescent confirmed by USP6 gene rearrangement

Am J Ophthalmol Case Rep. 2022 Mar 24:26:101496. doi: 10.1016/j.ajoc.2022.101496. eCollection 2022 Jun.

Authors

Douglas P Dworak¹, Amanda C Maltry², W Robert Bell²

Affiliations

¹ St. Paul Eye Clinic P.A., Woodbury, MN, USA.
² University of Minnesota Medical Center, Department of Ophthalmology and Visual Neurosciences, Department of Laboratory Medicine and Pathology, Minneapolis, MN, USA.

Abstract

Nodular fasciitis is a benign, idiopathic condition that can simulate both benign and malignant neoplasms. In adults, it generally occurs in the subcutaneous or superficial fascia of the trunk or upper extremities; occurrence in the periorbital region is far less common. We describe a case of a 16-year-old male with a 4-month history of a nodular, non-tender, progressively enlarging mass of the superotemporal periorbita. Histopathologic analysis of the excisional biopsy demonstrated nodular fasciitis, confirmed by molecular cytogenetic analysis that showed rearrangement of USP6.

Publication types

Case Reports