Follow-Up Comparison of Fluorescence Optical Imaging With Musculoskeletal Ultrasound for Early Detection of Psoriatic Arthritis

Juliane Büttner; Anne-Marie Glimm; Georgios Kokolakis; Magdalena Erdmann-Keding; Gerd-Rüdiger Burmester; Paula Hoff; Jens Klotsche; Sarah Ohrndorf

doi:10.3389/fmed.2022.845545

Follow-Up Comparison of Fluorescence Optical Imaging With Musculoskeletal Ultrasound for Early Detection of Psoriatic Arthritis

Front Med (Lausanne). 2022 Mar 18:9:845545. doi: 10.3389/fmed.2022.845545. eCollection 2022.

Authors

Juliane Büttner¹, Anne-Marie Glimm^{1

2}, Georgios Kokolakis³, Magdalena Erdmann-Keding^{3

4}, Gerd-Rüdiger Burmester¹, Paula Hoff^{1

5}, Jens Klotsche^{6

7}, Sarah Ohrndorf¹

Affiliations

¹ Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
² Department of Endocrinology, Nephrology and Rheumatology, Universitätsklinikum Leipzig, Leipzig, Germany.
³ Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
⁴ Haut- & Lasercentrum, Dr. Tanja Fischer und Kollegen, Potsdam - Berlin, Berlin, Germany.
⁵ Endokrinologikum Berlin am Gendarmenmarkt, Berlin, Germany.
⁶ German Rheumatism Research Centre Berlin (DRFZ), Leibniz Association, Berlin, Germany.
⁷ Institute for Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Abstract

Objectives: Early diagnosis of psoriatic arthritis (PsA) is crucial for a patient outcome but hampered by heterogenous manifestation and a lack of specific biomarkers. We recently showed that fluorescence optical imaging (FOI) can differentiate between patients with confirmed and suspected PsA. This study aims to follow-up (FU) patients with confirmed and suspected PsA focusing on patients with a change from suspected to confirmed PsA by the use of FOI in comparison with musculoskeletal ultrasound (MSUS).

Methods: Follow-up examination of patients included in the study performed by Erdmann-Keding et al. in which FOI of both hands was performed in a standardized manner using three predefined phases (p1-p3) and PrimaVista Mode (PVM). The comparison was drawn to grayscale-power Doppler (GS/PD) MSUS of the clinically dominant hand (wrist, MCP, PIP, DIP 2-5) from dorsal or palmar.

Results: Patients with a change from suspected to diagnosed PsA showed an increased prevalence of joints with pathological enhancement in FOI (p = 0.046) with an unchanged joint distribution pattern, especially with a dominant involvement of DIP joints. Compared to the baseline, these patients were three times more common to show enhancement in FOI p3 at FU. Newly detected pathologic joints by FOI (PVM, p2) and MSUS at FU were positively associated with the change of diagnosis from suspected to confirmed PsA (FOI: AUC 0.78; GSUS: AUC 0.77).

Conclusion: Fluorescence optical imaging appears to be a helpful tool to detect early PsA and to distinguish between acute and chronic disease stages. It could thereby become a suitable tool as a screening method to select psoriasis patients with an indication for further rheumatological evaluation.

Keywords: fluorescence optical imaging; follow-up studies (MeSH); hand; inflammation; psoriatic arthritis; ultrasound imaging.