Syntheses, Characterizations, and Inhibition Activities Against Coxsackievirus B3 of Iodobenzoic Hydrazide Functionalized Hexamolybdates

Long-Sheng Wang; Chao Guo; Da Hu; Yan-Xi Zhao; Hui-Hui Liu; Yu-Jia Dong; Shang-Bin Sun; Xing Liu; Kang-Hong Hu; Yan-Hong Wei

doi:10.3389/fchem.2022.841151

Syntheses, Characterizations, and Inhibition Activities Against Coxsackievirus B3 of Iodobenzoic Hydrazide Functionalized Hexamolybdates

Front Chem. 2022 Mar 17:10:841151. doi: 10.3389/fchem.2022.841151. eCollection 2022.

Authors

Long-Sheng Wang^{1

2}, Chao Guo¹, Da Hu³, Yan-Xi Zhao⁴, Hui-Hui Liu³, Yu-Jia Dong¹, Shang-Bin Sun¹, Xing Liu¹, Kang-Hong Hu³, Yan-Hong Wei³

Affiliations

¹ School of Material and Chemical Engineering, Hubei University of Technology, Wuhan, China.
² State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, CAS, Fuzhou, China.
³ National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Sino-German Biomedical Center, Hubei University of Technology, Wuhan, China.
⁴ Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education and Hubei Key Laboratory of Catalysis and Materials Science, South-Central University for Nationalities, Wuhan, China.

Abstract

A class of iodobenzoyldiazenido-functionalized POMs (TBA)₃ [Mo₆O₁₈(=N=NCOAr)] (Ar = Ph-o-I (1); Ph-m-I (2); Ph-p-I (3); Ph-3,4-I₂ (4); Ph-2,3,5-I₃ (5) (TBA = tetrabutylammonium) were prepared via the refluxing reaction of α-octamolybdates, DCC, and corresponding hydrazides in dry acetonitrile. Their structures were determined by Fourier-transform infrared spectroscopy, ultraviolet-visible spectra, X-ray photoelectron spectroscopy, hydrogen-1 nuclear magnetic resonance, and high-resolution mass spectrometry. Research on the biological activity of title compounds shows that L3, L5, 3, and 5 demonstrate potent inhibitory activity against coxsackievirus B3 and low in vitro cytotoxic activity against Hep-2 cell lines. The covalent linkage between the iodobenzoyldiazenido components and POMs can enhance the molecular inhibitory efficiency of iodobenzohydrazides.

Keywords: antiviral; coxsackievirus B3; functionalization; hydrazide; polyoxometalates.