Ifosfamide as a Cause of Fanconi Syndrome

Abstract

Ifosfamide-induced Fanconi syndrome is a rare complication that occurs in patients in treatment with ifosfamide. It is usually characterized by type II proximal renal tubular dysfunction, as evidenced by glycosuria, proteinuria, electrolyte loss, and metabolic acidosis. We outline two case reports of patients who received ifosfamide as chemotherapy for Ewing's sarcoma and extranodal B-cell lymphoma.

Keywords: chemotherapy; fanconi; glomerulopathy; hyperchloremic metabolic acidosis; ifosfamide; renal tubulopathy.