Severe COVID-19 Pneumonia and Genetic Susceptibility: A Case Report and Literature Review

Badr A Alsayed; Rashid Mir

doi:10.7759/cureus.23636

Severe COVID-19 Pneumonia and Genetic Susceptibility: A Case Report and Literature Review

Cureus. 2022 Mar 30;14(3):e23636. doi: 10.7759/cureus.23636. eCollection 2022 Mar.

Authors

Badr A Alsayed¹, Rashid Mir²

Affiliations

¹ Internal Medicine, University of Tabuk, Tabuk, SAU.
² Molecular Oncology, Genetics and Translational Medicine, Faculty of Applied Medical Sciences, Tabuk, SAU.

Abstract

Genetic susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) morbidity and mortality continues to evolve. This report presents a case of an apparently healthy male adult who developed severe coronavirus disease 2019 (COVID-19) and a study on relevant genetic mutations, namely, angiotensin-converting enzyme 2 (ACE2-rs4646994 I/D) gene, glutathione S-transferase (GST) M1 and T1 gene, and miR-423 rs6505162 C>A gene polymorphism. Results showed that the ACE-DD genotype of ACE2, (GSTM1+/+) (GSTT1-/-) genotype of GST gene, and CA genotype (heterozygosity) of miR-423 rs6505162 genes, which were found in the patient, could be independent risk factors of severe COVID-19, even without comorbidities.

Keywords: covid-19; gene polymorphism; genetic susceptibility; glutathione s-transferase; sars-cov-2.

Publication types

Case Reports