MiR-223 as a Regulator and Therapeutic Target in Liver Diseases

Jiarong Gu; Hao Xu; Yandong Chen; Na Li; Xin Hou

doi:10.3389/fimmu.2022.860661

MiR-223 as a Regulator and Therapeutic Target in Liver Diseases

Front Immunol. 2022 Mar 16:13:860661. doi: 10.3389/fimmu.2022.860661. eCollection 2022.

Authors

Jiarong Gu¹, Hao Xu¹, Yandong Chen¹, Na Li¹, Xin Hou^{1

2}

Affiliations

¹ School of Medicine, Ningbo University, Ningbo, China.
² The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China.

Abstract

MicroRNAs (miRNAs) are endogenous non-coding single-stranded small molecule RNAs consisting of 20-24 nucleotides that are highly conserved in species evolution. Expression of miRNAs is strictly tissue-specific, and it is chronological in fungi and plants, as well as in animals. MiR-223 has been shown to play a key role in innate immunity, and dysregulation of its expression contributes to the pathogenesis of multiple inflammatory diseases, and cancers. In this article the biosynthesis and functions of miR-223 in innate immunity are reviewed, and the role of miR-223 in liver physiopathology and therapeutic prospects are highlighted.

Keywords: inflammation; liver disease; macrophage; miR-223; neutrophil.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Immunity, Innate
Liver Diseases* / genetics
Liver Diseases* / therapy
MicroRNAs*
Neoplasms*

Substances

MicroRNAs