Exploring the Coordination of Cardiac Ion Channels With Action Potential Clamp Technique

Balázs Horváth; Norbert Szentandrássy; Csaba Dienes; Zsigmond M Kovács; Péter P Nánási; Ye Chen-Izu; Leighton T Izu; Tamas Banyasz

doi:10.3389/fphys.2022.864002

Exploring the Coordination of Cardiac Ion Channels With Action Potential Clamp Technique

Front Physiol. 2022 Mar 16:13:864002. doi: 10.3389/fphys.2022.864002. eCollection 2022.

Authors

Balázs Horváth¹, Norbert Szentandrássy^{1

2}, Csaba Dienes¹, Zsigmond M Kovács¹, Péter P Nánási^{1

2}, Ye Chen-Izu³, Leighton T Izu³, Tamas Banyasz¹

Affiliations

¹ Department of Physiology, University of Debrecen, Debrecen, Hungary.
² Department of Basic Medical Sciences, Faculty of Dentistry, University of Debrecen, Debrecen, Hungary.
³ Department of Pharmacology, University of California, Davis, Davis, CA, United States.

Abstract

The patch clamp technique underwent continual advancement and developed numerous variants in cardiac electrophysiology since its introduction in the late 1970s. In the beginning, the capability of the technique was limited to recording one single current from one cell stimulated with a rectangular command pulse. Since that time, the technique has been extended to record multiple currents under various command pulses including action potential. The current review summarizes the development of the patch clamp technique in cardiac electrophysiology with special focus on the potential applications in integrative physiology.

Keywords: action potential voltage clamp; cardiac electrophysiology; ion current; pharmacology; voltage clamp.

Publication types

Review

Abstract

Publication types

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