Helicobacter pylori Infection as a Risk Factor for Abnormal Serum Protein Levels in General Population of China

He Liu; Yan Qin; Jie Yang; Guoxiu Huang; Xiaoying Wei; Lulu Wang; Wei Li

doi:10.2147/JIR.S355446

Helicobacter pylori Infection as a Risk Factor for Abnormal Serum Protein Levels in General Population of China

J Inflamm Res. 2022 Mar 26:15:2009-2017. doi: 10.2147/JIR.S355446. eCollection 2022.

Authors

He Liu^#¹, Yan Qin^#¹, Jie Yang¹, Guoxiu Huang¹, Xiaoying Wei¹, Lulu Wang¹, Wei Li¹

Affiliation

¹ Department of Health Management, The People's Hospital of Guangxi Zhuang Autonomous Region & Research Center of Health Management, Guangxi Academy of Medical Sciences, Nanning, 530021, Guangxi, People's Republic of China.

^# Contributed equally.

Abstract

Background: Helicobacter pylori (HP) infection is considered as a risk factor for nutritional and metabolic abnormalities, and serum protein is an important marker of the nutritional and immune status. It is still unknown whether HP infection affects serum protein levels.

Methods: The participants who underwent health screening from July 2020 to August 2021 were included, among whom, 1485 subjects with 14C-urea breath test (14C-UBT) values ≥100 disintegrations per minute (dpm) were defined as HP-positive cases, and 4864 cases with 14C-UBT values <100 dpm were defined as HP-negative cases. Anthropometric measurements were taken, and biochemical parameters of the blood were analyzed for all subjects. Categorical variables were compared using the χ2 test and continuous variables using Student's t test. Logistic regression analysis was used to determine the effect of HP infection on serum proteins.

Results: Age, the proportion of female, globulin levels, total cholesterol levels, and low-density lipoprotein cholesterol levels were significantly higher in the HP infected group than in the non-infected group (P < 0.05). Height, weight, body mass index, hip circumference, albumin levels, albumin to globulin ratio, triglycerides levels, and uric acid levels were significantly higher in the non-infected group than in the infected group (P < 0.05). Multifactorial analysis revealed that HP infection was significantly associated with the risk of decreased serum albumin levels (odds ratio [OR] = 0.809, P = 3.51×10^-4); HP infection was significantly associated with the risk of increased serum globulin levels (model 1: OR = 1.257, P = 1.39× 10^-4); and HP infection was significantly associated with the risk of decreased albumin/globulin ratio (OR= 0.775, P = 2.30×10^-5).

Conclusion: HP infection was significantly associated with lower serum albumin levels, elevated globulin levels, and lower albumin/globulin ratio. Thus, it is an important factor affecting nutritional metabolism.

Keywords: Helicobacter pylori; albumin/globulin ratio; nutrition; serum albumin; serum globulin.

Grants and funding

This work was supported by the Scientific research project funded by Guangxi Zhuang Autonomous Region Health and Health Commission Self-Financed Research Projects (NO. Z20201318).