Role of Pyroptosis in Respiratory Diseases and its Therapeutic Potential

Jingjing Liu; Guoqing Fan; Ningning Tao; Tieying Sun

doi:10.2147/JIR.S352563

Role of Pyroptosis in Respiratory Diseases and its Therapeutic Potential

J Inflamm Res. 2022 Mar 28:15:2033-2050. doi: 10.2147/JIR.S352563. eCollection 2022.

Authors

Jingjing Liu^{1

2

3}, Guoqing Fan^{1

2

3}, Ningning Tao⁴, Tieying Sun^{1

2}

Affiliations

¹ Department of Respiratory Medicine and Critical Care, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
² Graduate School of Peking Union Medical College, Beijing, People's Republic of China.
³ The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, People's Republic of China.
⁴ Department of Respiratory Medicine and Critical Care, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, People's Republic of China.

Abstract

Pyroptosis is an inflammatory type of regulated cell death that is dependent on inflammasome activation and downstream proteases such as caspase-1 or caspase 4/5/11. The main executors are gasdermins, which have an inherent pore-forming function on the membrane and release inflammatory cytokines, such as interleukin (IL)-1β, IL-18 and high mobility group box 1. Emerging evidence demonstrates that pyroptosis is involved in the pathogenesis of various pulmonary diseases. In this review, we mainly discuss the biological mechanisms of pyroptosis, explore the relationship between pyroptosis and respiratory diseases, and discuss emerging therapeutic strategies for respiratory diseases.

Keywords: caspase-1; caspase-4/5/11; gasdermins; pulmonary disease; pyroptosis.

Publication types

Review