Serum and cerebrospinal fluid acyclovir pharmacokinetics in a neonate with HSV-2 meningoencephalitis

Kensuke Shoji; Jumpei Saito; Yusa Nagai; Itaru Hayakawa; Yusuke Oho; Hiroki Kato; Chiaki Tao; Takanori Funaki; Masaki Yamada; Chikara Ogimi

doi:10.1016/j.jiac.2022.03.022

Serum and cerebrospinal fluid acyclovir pharmacokinetics in a neonate with HSV-2 meningoencephalitis

J Infect Chemother. 2022 Aug;28(8):1168-1171. doi: 10.1016/j.jiac.2022.03.022. Epub 2022 Mar 31.

Authors

Kensuke Shoji¹, Jumpei Saito², Yusa Nagai³, Itaru Hayakawa³, Yusuke Oho², Hiroki Kato⁴, Chiaki Tao⁵, Takanori Funaki⁵, Masaki Yamada⁶, Chikara Ogimi⁵

Affiliations

¹ Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan. Electronic address: shoji-k@ncchd.go.jp.
² Department of Pharmacy, National Center for Child Health and Development, Tokyo, Japan.
³ Division of Neurology, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan.
⁴ Division of Critical Care Medicine, National Center for Child Health and Development, Tokyo, Japan.
⁵ Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan.
⁶ Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan; Department for Advanced Medicine for Viral Infections, National Center for Child Health and Development, Tokyo, Japan.

PMID: 35370079
DOI: 10.1016/j.jiac.2022.03.022

Abstract

A neonatal patient with Herpes simplex virus type-2 meningoencephalitis was treated by high-dose intravenous acyclovir therapy. Serum and cerebrospinal fluid (CSF) concentrations were measured retrospectively, showing that the CSF-to-serum concentration ratio was 0.67-0.71, which was higher than the previously reported values in other age groups.

Keywords: Acyclovir; HSV-2; Neonate; Pharmacokinetics.

MeSH terms

Acyclovir / therapeutic use
Antiviral Agents / therapeutic use
Cerebrospinal Fluid
Herpes Simplex* / drug therapy
Herpesvirus 2, Human
Humans
Infant, Newborn
Meningoencephalitis* / drug therapy
Retrospective Studies

Substances

Antiviral Agents
Acyclovir