Sesquiterpenoids from the leaves of Sarcandra glabra

Chin J Nat Med. 2022 Mar;20(3):215-220. doi: 10.1016/S1875-5364(21)60102-4.

Abstract

Sarglanoids A-F, six new sesquiterpenoids belonging to eudesmane (1-5) and eremophilane (6) types, were isolated from the leaves of Sarcandra glabra, a famous traditional Chinese medicine (TCM). Their structures including absolute configurations were elucidated through extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. Compounds 1-2 were rare N-containing eudesmane-type sesquiterpenoids. Compound 3 exhibited inhibitory activity against nitric oxide (NO) production in lipopolysaccharides (LPS)-induced RAW 264.7 cells with IC50 values at 20.00 ± 1.30 μmol·L-1. These findings provide scientific evidence for sesquiterpenoids as the material foundation of S. glabra.

Keywords: Anti-inflammatory; N-containing sesquiterpenoids; Sarcandra glabra; Sesquiterpenoids.

MeSH terms

  • Molecular Structure
  • Plant Leaves
  • Polycyclic Sesquiterpenes
  • Seeds
  • Sesquiterpenes* / chemistry
  • Sesquiterpenes* / pharmacology

Substances

  • Polycyclic Sesquiterpenes
  • Sesquiterpenes