Recent trends of natural based therapeutics for mitochondria targeting in Alzheimer's disease

Abstract

Alzheimer's disease (AD) is the most ubiquitous neurodegenerative disorder with impaired cognitive functionality. Till date, the specific pathophysiology related to AD is still elusive. Recent reports suggest mitochondrial dysfunctionality like oxidative stress, Ca²⁺ disbalance, apoptosis, decrease energy and its metabolism plays an important. Recent reports about mitochondrial mechanisms and dynamics in AD unravelled new insights of molecular targets. Targeting multi-pathway via natural products may attenuate and prevent the mitochondria dysfunctionality. In this review, we have focused on the pathophysiology events of mitochondrial dysfunction in AD as well as mitochondrial fusion and fission mechanisms, role of aging in multicellular organisms, and how these connect to cell cycle regulation, and transmission of energy status.

Keywords: Alzheimer’s disease; Apoptosis; Clinical; Mitochondria; Phytochemicals; Reactive oxygen species (ROS).