Inflammatory profiles in plasma and cerebrospinal fluid of patients with neurosarcoidosis

Keld-Erik Byg; Zsolt Illes; Tobias Sejbaek; Kate L Lambertsen; Torkell Ellingsen; Helle H Nielsen

doi:10.1016/j.jneuroim.2022.577849

Inflammatory profiles in plasma and cerebrospinal fluid of patients with neurosarcoidosis

J Neuroimmunol. 2022 Jun 15:367:577849. doi: 10.1016/j.jneuroim.2022.577849. Epub 2022 Mar 26.

Authors

Keld-Erik Byg¹, Zsolt Illes², Tobias Sejbaek³, Kate L Lambertsen⁴, Torkell Ellingsen⁵, Helle H Nielsen²

Affiliations

¹ Rheumatology Research Unit, Odense University Hospital, J.B. Winsloewsvej 4, 5000 Odense, Denmark; Department of Neurology, Odense University Hospital, J.B. Winsloewsvej 4, 5000 Odense, Denmark; BRIDGE-Brain Research-Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, J.B. Winsloewsvej 19, 5000 Odense, Denmark; Department of Clinical Research, University of Southern Denmark, J.B. Winsloewsvej 19, 5000 Odense, Denmark; Open Patient data Explorative Network, Odense University Hospital, J.B. Winsloewsvej 9a, 5000 Odense, Denmark.. Electronic address: keld-erik.byg@rsyd.dk.
² Department of Neurology, Odense University Hospital, J.B. Winsloewsvej 4, 5000 Odense, Denmark; BRIDGE-Brain Research-Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, J.B. Winsloewsvej 19, 5000 Odense, Denmark; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsloewsvej 21, 5000 Odense, Denmark.
³ Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsloewsvej 21, 5000 Odense, Denmark; Department of Neurology, South West Jutland University Hospital of Southern Denmark, Finsensgade 35, 6700 Esbjerg, Denmark; Department of Regional Health Research, University of Southern Denmark, J.B. Winsloewsvej 19, 5000 Odense, Denmark.
⁴ BRIDGE-Brain Research-Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, J.B. Winsloewsvej 19, 5000 Odense, Denmark; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsloewsvej 21, 5000 Odense, Denmark.
⁵ Rheumatology Research Unit, Odense University Hospital, J.B. Winsloewsvej 4, 5000 Odense, Denmark; Department of Clinical Research, University of Southern Denmark, J.B. Winsloewsvej 19, 5000 Odense, Denmark.

PMID: 35366560
DOI: 10.1016/j.jneuroim.2022.577849

Abstract

Methods: Cerebrospinal fluid (CSF) and plasma levels of 38 biomarkers from 20 neurosarcoidosis (NS) patients were compared to healthy controls (HC).

Results: In CSF, 25 biomarkers were significantly elevated compared to HC: IFNγ, TNFα, TNFβ, IL-2, IL-6, IL-10, IL-12B, IL-15, IL-16, CCL2, CCL3, CCL4, CCL11, CCL13, CCL17, CCL22, CCL26, CXCL8, CXCL10, TNFR2, VEGF-A, PIGF, SAA, VCAM1, and ICAM1. In plasma, 12 biomarkers were significantly elevated compared to HC: IFNγ, TNFα, CCL2, CCL3, CCL4, CCL17, CXCL10, VEGFR1, PIGF, SAA, VCAM1, and ICAM1.

Conclusion: NS patients have profoundly elevated cytokines, chemokines, vascular angiogenesis, and vascular injury biomarkers in CSF and plasma.

Keywords: Biomarkers; Chemokines; Cytokines; Neurosarcoidosis; Vascular angiogenesis; Vascular injury.

MeSH terms

Biomarkers
Central Nervous System Diseases* / blood
Central Nervous System Diseases* / cerebrospinal fluid
Chemokines*
Cytokines*
Humans
Sarcoidosis* / blood
Sarcoidosis* / cerebrospinal fluid

Substances

Biomarkers
Chemokines
Cytokines

Supplementary concepts

Neurosarcoidosis