Study protocol: MyoFit46-the cardiac sub-study of the MRC National Survey of Health and Development

Matthew Webber; Debbie Falconer; Mashael AlFarih; George Joy; Fiona Chan; Clare Davie; Lee Hamill Howes; Andrew Wong; Alicja Rapala; Anish Bhuva; Rhodri H Davies; Christopher Morton; Jazmin Aguado-Sierra; Mariano Vazquez; Xuyuan Tao; Gunther Krausz; Slobodan Tanackovic; Christoph Guger; Hui Xue; Peter Kellman; Iain Pierce; Jonathan Schott; Rebecca Hardy; Nishi Chaturvedi; Yoram Rudy; James C Moon; Pier D Lambiase; Michele Orini; Alun D Hughes; Gabriella Captur

doi:10.1186/s12872-022-02582-0

Study protocol: MyoFit46-the cardiac sub-study of the MRC National Survey of Health and Development

BMC Cardiovasc Disord. 2022 Apr 1;22(1):140. doi: 10.1186/s12872-022-02582-0.

Authors

Matthew Webber^{1

2

3

4}, Debbie Falconer³, Mashael AlFarih², George Joy^{1

2}, Fiona Chan^{1

2}, Clare Davie⁴, Lee Hamill Howes⁴, Andrew Wong⁴, Alicja Rapala⁴, Anish Bhuva^{1

2

5}, Rhodri H Davies^{1

2}, Christopher Morton⁶, Jazmin Aguado-Sierra^{6

7}, Mariano Vazquez^{6

7}, Xuyuan Tao⁸, Gunther Krausz⁹, Slobodan Tanackovic⁹, Christoph Guger⁹, Hui Xue¹⁰, Peter Kellman¹⁰, Iain Pierce^{1

2}, Jonathan Schott¹¹, Rebecca Hardy¹², Nishi Chaturvedi⁴, Yoram Rudy^{13

14}, James C Moon^{1

2}, Pier D Lambiase^{1

2}, Michele Orini^{2

4}, Alun D Hughes^{2

4}, Gabriella Captur^{15

16

17}

Affiliations

¹ Barts Heart Centre, Barts Health NHS Trust, West Smithfield, London, ECIA 7BE, UK.
² Institute of Cardiovascular Science, University College London, Huntley Street, London, WC1E 6DD, UK.
³ Centre for Inherited Heart Muscle Conditions, Department of Cardiology, Royal Free London NHS Foundation Trust, Pond Street, London, NW3 2QG, UK.
⁴ Medical Research Council Unit for Lifelong Health and Ageing at UCL, 1-19 Torrington Place, London, WC1E 7HB, UK.
⁵ Institute of Health Informatics, UCL, Euston Road, London, UK.
⁶ ELEM Biotech, S.L, Bristol, BS1 6QH, UK.
⁷ Barcelona Supercomputing Center (BSC), 08034, Barcelona, Spain.
⁸ École Nationale Supérieure Des Arts Et Industries Textiles, 2 allée Louise et Victor Champier, 59056, Roubaix Cedex 1, France.
⁹ g.Tec Medical Engineering GmbH, Siernigtrabe 14, 4521, Schiedlberg, Austria.
¹⁰ National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
¹¹ Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
¹² CLOSER, 55-59 Gordon Square, London, WC1H 0NU, UK.
¹³ Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO, 63130, USA.
¹⁴ Department of Biomedical Engineering, Washington University, St. Louis, MO, 63130, USA.
¹⁵ Institute of Cardiovascular Science, University College London, Huntley Street, London, WC1E 6DD, UK. gabriella.captur@ucl.ac.uk.
¹⁶ Centre for Inherited Heart Muscle Conditions, Department of Cardiology, Royal Free London NHS Foundation Trust, Pond Street, London, NW3 2QG, UK. gabriella.captur@ucl.ac.uk.
¹⁷ Medical Research Council Unit for Lifelong Health and Ageing at UCL, 1-19 Torrington Place, London, WC1E 7HB, UK. gabriella.captur@ucl.ac.uk.

Abstract

Background: The life course accumulation of overt and subclinical myocardial dysfunction contributes to older age mortality, frailty, disability and loss of independence. The Medical Research Council National Survey of Health and Development (NSHD) is the world's longest running continued surveillance birth cohort providing a unique opportunity to understand life course determinants of myocardial dysfunction as part of MyoFit46-the cardiac sub-study of the NSHD.

Methods: We aim to recruit 550 NSHD participants of approximately 75 years+ to undertake high-density surface electrocardiographic imaging (ECGI) and stress perfusion cardiovascular magnetic resonance (CMR). Through comprehensive myocardial tissue characterization and 4-dimensional flow we hope to better understand the burden of clinical and subclinical cardiovascular disease. Supercomputers will be used to combine the multi-scale ECGI and CMR datasets per participant. Rarely available, prospectively collected whole-of-life data on exposures, traditional risk factors and multimorbidity will be studied to identify risk trajectories, critical change periods, mediators and cumulative impacts on the myocardium.

Discussion: By combining well curated, prospectively acquired longitudinal data of the NSHD with novel CMR-ECGI data and sharing these results and associated pipelines with the CMR community, MyoFit46 seeks to transform our understanding of how early, mid and later-life risk factor trajectories interact to determine the state of cardiovascular health in older age.

Trial registration: Prospectively registered on ClinicalTrials.gov with trial ID: 19/LO/1774 Multimorbidity Life-Course Approach to Myocardial Health- A Cardiac Sub-Study of the MCRC National Survey of Health and Development (NSHD).

Keywords: 4-dimensional flow; Cardiovascular health; Cardiovascular magnetic resonance; Electrocardiographic imaging; Life course risk factors; Myocardial tissue characterization; Perfusion; Risk trajectories; Subclinical myocardial dysfunction.

Publication types

Clinical Trial Protocol

MeSH terms

Aged
Cardiovascular Diseases* / diagnostic imaging
Cardiovascular Diseases* / epidemiology
Health Surveys
Heart
Humans
Magnetic Resonance Imaging*
Myocardium

Abstract

Publication types

MeSH terms

Grants and funding