Comorbidity of Type 2 Diabetes Mellitus and Depression: Clinical Evidence and Rationale for the Exacerbation of Cardiovascular Disease

Mengmeng Zhu; Yiwen Li; Binyu Luo; Jing Cui; Yanfei Liu; Yue Liu

doi:10.3389/fcvm.2022.861110

Comorbidity of Type 2 Diabetes Mellitus and Depression: Clinical Evidence and Rationale for the Exacerbation of Cardiovascular Disease

Front Cardiovasc Med. 2022 Mar 10:9:861110. doi: 10.3389/fcvm.2022.861110. eCollection 2022.

Authors

Mengmeng Zhu¹, Yiwen Li¹, Binyu Luo¹, Jing Cui¹, Yanfei Liu², Yue Liu¹

Affiliations

¹ National Clinical Research Centre for Chinese Medicine Cardiology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China.
² Second Department of Geriatrics, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China.

Abstract

Depression is a common comorbidity of type 2 diabetes mellitus (T2DM). T2DM with comorbid depression increases the risk of cardiovascular events and death. Depression and T2DM and its macrovascular complications exhibited a two-way relationship. Regarding treatment, antidepressants can affect the development of T2DM and cardiovascular events, and hypoglycemic drugs can also affect the development of depression and cardiovascular events. The combination of these two types of medications may increase the risk of the first myocardial infarction. Herein, we review the latest research progress in the exacerbation of cardiovascular disease due to T2DM with comorbid depression and provide a rationale and an outlook for the prevention and treatment of cardiovascular disease in T2DM with comorbid depression.

Keywords: cardiovascular disease; clinical evidence; depression; outlook; type 2 diabetes mellitus (T2DM).

Publication types

Review