Transition From Parenteral to Enteral Nutrition and Postnatal Growth in Very Preterm Infants During Their First 28 Days of Life

Na Wang; Jia Zhang; Bo Wang; Zhangbin Yu; Shuping Han; Huaiyan Wang; Rongrong Chen; Li Gu; Yan Gao; Weiwei Hou; Xingxing Lu

doi:10.3389/fped.2022.775667

Transition From Parenteral to Enteral Nutrition and Postnatal Growth in Very Preterm Infants During Their First 28 Days of Life

Front Pediatr. 2022 Mar 10:10:775667. doi: 10.3389/fped.2022.775667. eCollection 2022.

Authors

Na Wang¹, Jia Zhang¹, Bo Wang¹, Zhangbin Yu², Shuping Han², Huaiyan Wang³, Rongrong Chen⁴, Li Gu⁴, Yan Gao⁵, Weiwei Hou⁶, Xingxing Lu⁶

Affiliations

¹ Department of Pediatrics, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian, China.
² Department of Neonatology, Nanjing Maternity and Child Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, China.
³ Department of Neonatology, Changzhou Maternity and Child Health Care Hospital, Changzhou, China.
⁴ Department of Neonatology, Nantong Maternity and Child Health Care Hospital, Nantong, China.
⁵ Department of Neonatology, Lianyungang Maternity and Child Health Care Hospital, Lianyungang, China.
⁶ Department of Neonatology, Northern Jiangsu People's Hospital, Yangzhou, China.

Abstract

Background: Nutrition practices for preterm infants during the first few weeks of life can be divided into three phases: the parenteral nutrition (PN), enteral nutrition (EN), and transition (TN) phases; the TN phase includes both PN and EN. Our purpose was to analyze nutrition practices for very preterm infants during the TN phase and their association with the infants' growth during the first 28 days of life.

Methods: Data from 268 very preterm infants <32 weeks old from six neonatal intensive care units were analyzed retrospectively. The TN phase was defined as enteral feedings of 30-120 ml/kg/d. Postnatal growth failure (PGF) was defined as a 28-day growth velocity <15 g/kg/d. Differences in protein and energy intake between the PGF and non-PGF groups during the TN phase were calculated, and risk factors for PGF were identified using multivariate regression analysis.

Results: The total protein (parenteral + enteral) intake during the TN was 3.16 (2.89, 3.47) g/kg/d, which gradually decreased as the enteral feeding volume increased in the TN phase. The total energy (parenteral + enteral) intake during the TN phase was 115.72 (106.98, 122.60) kcal/kg/d. The PGF group had a lower total protein intake (parenteral + enteral) than the non-PGF group had [3.09 (2.85, 3.38) g/kg/d vs. 3.27 (3.06, 3.57) g/kg/d, P = 0.007, respectively]. No significant difference was found in energy intake during the TN phase. The variables associated with PGF included a lower total protein (parenteral + enteral) intake, a smaller day of age at the end of the TN phase, and a higher birth weight z-score.

Conclusion: Increasing the total protein intake (parenteral + enteral) during the TN could reduce the incidence of PGF.

Keywords: enteral nutrition; first 28 days of life; growth; parenteral nutrition; premature [MeSH].