Focal Epilepsy in Individuals with Laron Syndrome

Abstract

Objective: The aim of the study was to describe focal epilepsy in patients with Laron syndrome (LS).

Methods: Data were retrieved from medical records of a single-center cohort of 75 patients with LS.

Results: We describe for the first time 4 patients with concomitant focal epilepsy and LS. Two of them experienced episodes of status epilepticus. Electroencephalogram examination in all 4 patients showed interictal epileptiform discharges in the temporal regions. Three achieved long-term seizure freedom on antiseizure medications.

Conclusion: Patients with LS may be at risk of developing focal epilepsy, which seems to be unrelated to hypoglycemic episodes in childhood.

Keywords: Epilepsy; Insulin-like growth factor-1; Laron syndrome; Seizures.