Genomic characterization of a multi-drug resistant, CTX-M-65-producing clinical isolate of Salmonella Infantis isolated in Brazil

Microbes Infect. 2022 Jul-Aug;24(5):104972. doi: 10.1016/j.micinf.2022.104972. Epub 2022 Mar 28.

Abstract

A multi-drug resistant, CTX-M-65 producing Salmonella Infantis was identified from a patient in Brazil. Whole genome sequencing followed by hybrid assembly (short and long reads) indicated the presence of blaCTX-M-65 in a pESI-like megaplasmid in this ST32 isolate and phylogenetic analysis showed high similarity with IncFIB S. Infantis isolates from food and poultry in the USA.

Keywords: Antimicrobial resistance; Plasmids; Salmonella infantis; Whole genome sequencing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Brazil
  • Drug Resistance, Multiple, Bacterial*
  • Genomics
  • Humans
  • Phylogeny
  • Plasmids
  • Salmonella enterica* / drug effects
  • Salmonella enterica* / genetics
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • beta-Lactamases