Evaluation and Preparation of a Designed Kartogenin Drug Delivery System (DDS) of Hydrazone-Linkage-Based pH Responsive mPEG-Hz- b-PCL Nanomicelles for Treatment of Osteoarthritis

Wen-Ta Su; Ching-Cheng Huang; Hsia-Wei Liu

doi:10.3389/fbioe.2022.816664

Evaluation and Preparation of a Designed Kartogenin Drug Delivery System (DDS) of Hydrazone-Linkage-Based pH Responsive mPEG-Hz- b-PCL Nanomicelles for Treatment of Osteoarthritis

Front Bioeng Biotechnol. 2022 Mar 9:10:816664. doi: 10.3389/fbioe.2022.816664. eCollection 2022.

Authors

Wen-Ta Su¹, Ching-Cheng Huang², Hsia-Wei Liu^{3

4}

Affiliations

¹ Graduate Institute of Biochemical and Biomedical Engineering, National Taipei University of Technology, Taipei, Taiwan.
² Department of Biomedical Engineering, Ming-Chuan University, Taipei, Taiwan.
³ Department Life Science, Fu Jen Catholic University, New Taipei City, Taiwan.
⁴ Graduate Institute of Applied Science and Engineering, Fu Jen Catholic University, New Taipei City, Taiwan.

Abstract

Osteoarthritis (OA) is a chronic disease caused by the damage of articular cartilage. Kartogenin (KGN) is a well-recognized small molecule which could induce MSCs chondrogenesis and promote cartilage repair treatments. Nano-level micells could be a suitable drug carrier technology for the treatments. In this study, the acid-responsive methoxy poly(ethylene oxide)-hydrazone-poly(ε-caprolactone) copolymers, mPEG-Hz-b-PCL, were synthesized. The structure was characterized by ¹H NMR. The evaluation of a designed kartogenin drug delivery system (DDS) of hydrazone-linkage-based pH responsive mPEG-Hz-b-PCL nanomicelles for treatment of osteoarthritis could be carried out.

Keywords: hydrazone-linkage; kartogenin; methoxy poly(ethylene oxide); nanomicelles; poly(ε-caprolactone).