Isolevuglandins Scavenger Ameliorates Myocardial Ischemic Injury by Suppressing Oxidative Stress, Apoptosis, and Inflammation

Junjie Guo; Fengqiang Xu; Hongwei Ji; Yajun Jing; Li Shen; Xinyu Weng; Longgang Hu

doi:10.3389/fcell.2022.836035

Isolevuglandins Scavenger Ameliorates Myocardial Ischemic Injury by Suppressing Oxidative Stress, Apoptosis, and Inflammation

Front Cell Dev Biol. 2022 Mar 9:10:836035. doi: 10.3389/fcell.2022.836035. eCollection 2022.

Authors

Junjie Guo^{1

2}, Fengqiang Xu^{1

2}, Hongwei Ji^{1

2}, Yajun Jing³, Li Shen^{4

5

6}, Xinyu Weng^{4

5

6}, Longgang Hu⁷

Affiliations

¹ Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, China.
² Qingdao Municipal Key Laboratory of Hypertension (Key Laboratory of Cardiovascular Medicine), Qingdao, China.
³ Department of Critical Care Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China.
⁴ Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University, Shanghai, China.
⁵ Key Laboratory of Viral Heart Diseases, National Health Commission, Shanghai, China.
⁶ Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai, China.
⁷ Department of Cardiology, The Affiliated Cardiovascular Hospital of Qingdao University, Qingdao, China.

Abstract

Augmented levels of reactive isolevuglandins (IsoLGs) are responsible for cardiovascular diseases. The role of IsoLGs in myocardial infarction (MI) remains elusive. Here we explored the effect of IsoLGs scavenger 2-hydroxybenzylamine (2-HOBA) in post-infarction cardiac repair. We observed that infarcted cardiac tissues expressed high IsoLGs in mice. Following MI injury, 2-HOBA treated mice displayed decreased infarction area and improved heart function compared with the saline-treated group. Moreover, 2-HOBA effectively attenuated MI-induced cardiac remodeling, oxidative stress, apoptosis, and inflammation. 4-hydroxybenzylamine (4-HOBA), a less reactive isomer of 2-HOBA, barely antagonized the MI-induced injury. These findings suggest that IsoLGs elimination may be helpful in MI therapy.

Keywords: apoptosis; cardiac remodeling; inflammation; isolevuglandin scavenger; myocadial infarction; oxidative stress.