Risk Factors for Invasive Meningococcal Disease Belonging to a Novel Urethritis Clade of Neisseria meningitidis-United States, 2013-2017

Open Forum Infect Dis. 2022 Jan 25;9(4):ofac035. doi: 10.1093/ofid/ofac035. eCollection 2022 Apr.

Abstract

We describe cases of invasive meningococcal disease caused by nongroupable Neisseria meningitidis belonging to a novel phylogenetic clade associated with urethritis. Seven cases were identified, comprising 0.6% of sequenced invasive meningococcal disease isolates from 2013 to 2017. Five patients had a known or likely immunocompromising condition, including 2 with a complement deficiency.

Keywords: Neisseria meningitidis; meningococcal disease; novel urethritis clade.