Effects of aging on basement membrane of tibialis anterior muscle during recovery following muscle injury in rats

Yuji Kanazawa; Mamoru Nagano; Satoshi Koinuma; Shinichi Sugiyo; Yasufumi Shigeyoshi

doi:10.1093/jmicro/dfac016

Effects of aging on basement membrane of tibialis anterior muscle during recovery following muscle injury in rats

Microscopy (Oxf). 2022 Aug 1;71(4):245-248. doi: 10.1093/jmicro/dfac016.

Authors

Yuji Kanazawa^{1

2}, Mamoru Nagano², Satoshi Koinuma², Shinichi Sugiyo³, Yasufumi Shigeyoshi²

Affiliations

¹ Department of Medical Technology and Clinical Engineering, Hokuriku University, Kanazawa 920-1180, Japan.
² Department of Anatomy and Neurobiology, Graduate School of Medical Sciences, Kindai University, Ohnohigashi, Osakasayama 589-8511, Japan.
³ Department of Physical Therapy, Osaka University of Human Sciences, Shojyaku, Settsu 566-8501, Japan.

Abstract

We investigated the effect of aging on the basement membrane (BM) during postinjury muscle recovery. Using a rat model, we found that aging delayed muscle fiber and BM recovery. In addition, expression of BM-related factors peaked 7 days after muscle injury among both young and older rats. Peak expression of collagen IV synthetic factors decreased with age, whereas expression of the degradative factor was unaffected by age. These results suggest that age-related delays in postinjury muscle fiber and BM recovery may be related to the suppression of collagen IV synthetic factors.

Keywords: aging; basement membrane; collagen IV; muscle injury; recovery; skeletal muscle.

MeSH terms

Aging*
Animals
Basement Membrane / metabolism
Collagen / metabolism
Muscle Fibers, Skeletal
Muscle, Skeletal* / metabolism
Rats

Substances

Collagen

Grants and funding

Hokuriku University Special Research Grant