Thyroid dysfunction on the heart: clinical effects, prognostic impact and management strategies

Giulia Mattesi; Sara Di Michele; Donato Mele; Ilaria Rigato; Riccardo Bariani; Andrea Fiorencis; Marco Previtero; Abdullah Al Sergani; Loira Leoni; Barbara Bauce; Valeria Pergola

doi:10.4081/monaldi.2022.2145

Thyroid dysfunction on the heart: clinical effects, prognostic impact and management strategies

Monaldi Arch Chest Dis. 2022 Mar 24;92(4). doi: 10.4081/monaldi.2022.2145.

Authors

Affiliations

¹ Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, Padua. giulia.mattesi@aopd.veneto.it.
² Cardiology Division, San Filippo Neri Hospital, Rome. sara_dimichele@yahoo.it.
³ Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, Padua. donato.mele@uipd.it.
⁴ Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, Padua. ilaria.rigato@aopd.veneto.it.
⁵ Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, Padua. riccardo.bariani@unipd.it.
⁶ Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, Padua. Info@andreafiorencis.it.
⁷ Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, Padua. marco.previtero@aopd.veneto.it.
⁸ King Faisal Specialist Hospital & Research Centre, The Heart Centre, Riyadh. Abdullahalsergani@gmail.com.
⁹ Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, Padua. loira.leoni@aopd.veneto.it.
¹⁰ Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, Padua. barbara.bauce@unipd.it.
¹¹ Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, Padua. valeria.pergola@aopd.veneto.it.

PMID: 35347972
DOI: 10.4081/monaldi.2022.2145

Abstract

Thyroid hormones have a considerable influence on cardiac function and structure. There are direct and indirect effects of thyroid hormone on the cardiovascular system, which are prominent in both hypothyroidism and hyperthyroidism. In this review, we discuss how thyroid dysfunction impacts cardiovascular pathophysiology and the underlying molecular mechanisms.

Publication types

Review

MeSH terms

Cardiovascular Diseases*
Humans
Hyperthyroidism* / complications
Hyperthyroidism* / diagnosis
Hyperthyroidism* / therapy
Hypothyroidism* / complications
Prognosis
Thyroid Hormones / physiology
Thyroid Hormones / therapeutic use

Substances

Thyroid Hormones