Diabetes Mellitus and Oral Cancer: A Retrospective Study from Austria

Anticancer Res. 2022 Apr;42(4):1899-1903. doi: 10.21873/anticanres.15666.

Abstract

Aim: This study aimed to analyse the possible linkage between diabetes mellitus (DM) and oral cancer among Austrians.

Patients and methods: We performed a retrospective DM and/or impaired fasting glucose (IFG) screening in 573 patients who underwent maxillofacial surgery under general anaesthesia between January 1, 2018 and December 31, 2019.

Results: Of the total patients, 26.5% (n=152) had cancer diagnosis, whereas the remaining 73.5% (n=421) formed the control group. The prevalence of glucose metabolism disorder (GMD) was significantly (p<0.00001) more common among cancer patients (59.9% vs. 36.5%). Squamous cell carcinoma and sublingual tumours represented the most common tumour type (93.4%) and location (35.5%), respectively. Smoking was significantly (p=0.00093) more common within the cancer group.

Conclusion: Our data suggest an association between GMD and oral cancer.

Keywords: Diabetes mellitus; epidemiology; glucose metabolism disorder; maxillofacial surgery; mouth neoplasms.

MeSH terms

  • Austria / epidemiology
  • Blood Glucose / metabolism
  • Diabetes Mellitus* / diagnosis
  • Diabetes Mellitus* / epidemiology
  • Humans
  • Mouth Neoplasms* / epidemiology
  • Mouth Neoplasms* / etiology
  • Retrospective Studies

Substances

  • Blood Glucose