Phagolysosomal remodeling to confine Candida albicans in the macrophage

Neuza Domingues; Teresa Gonçalves; Henrique Girao

doi:10.1016/j.tim.2022.03.004

Phagolysosomal remodeling to confine Candida albicans in the macrophage

Trends Microbiol. 2022 Jun;30(6):519-523. doi: 10.1016/j.tim.2022.03.004. Epub 2022 Mar 25.

Authors

Neuza Domingues¹, Teresa Gonçalves², Henrique Girao³

Affiliations

¹ Univ Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, Coimbra, Portugal; Univ Coimbra, Faculty of Medicine, Coimbra, Portugal; Univ Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), Coimbra, Portugal; Academic and Clinical Center of Coimbra, Coimbra, Portugal.
² Univ Coimbra, Faculty of Medicine, Coimbra, Portugal; Univ Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), Coimbra, Portugal; Academic and Clinical Center of Coimbra, Coimbra, Portugal; CNC-Center for Neurosciences and Cell Biology, Coimbra, Portugal.
³ Univ Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, Coimbra, Portugal; Univ Coimbra, Faculty of Medicine, Coimbra, Portugal; Univ Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), Coimbra, Portugal; Academic and Clinical Center of Coimbra, Coimbra, Portugal. Electronic address: hmgirao@fmed.uc.pt.

PMID: 35346551
DOI: 10.1016/j.tim.2022.03.004

Abstract

Macrophages play a crucial role in fungal clearance during Candida albicans infection. In order to eliminate the intracellular fungi and survive, macrophages need to quickly respond to the dimorphic transition by repairing the phagolysosomal membrane. Also, actin-contractile rings were recently suggested as a powerful weapon to dampen hyphal growth.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Actins
Candida albicans*
Candidiasis* / microbiology
Humans
Hyphae
Macrophages / microbiology

Substances

Actins