Synthesis of a Bioactive Composition of Chitosan-Selenium Nanoparticles

K V Apryatina; E I Murach; S V Amarantov; E I Erlykina; V S Veselov; L A Smirnova

doi:10.1134/S0003683822020028

Synthesis of a Bioactive Composition of Chitosan-Selenium Nanoparticles

Appl Biochem Microbiol. 2022;58(2):126-131. doi: 10.1134/S0003683822020028. Epub 2022 Mar 24.

Authors

K V Apryatina¹, E I Murach², S V Amarantov³, E I Erlykina², V S Veselov¹, L A Smirnova¹

Affiliations

¹ National Research Lobachevsky State University of Nizhny Novgorod, 603022 Nizhny Novgorod, Russia.
² Privolzhsky Research Medical University, 603005 Nizhny Novgorod, Russia.
³ Federal Scientific Research Center "Crystallography and Photonics" of RAS, Institute of Crystallography Named After A. Shubnikov RAS, 119333 Moscow, Russia.

Abstract

A biologically active composition of chitosan-selenium nanoparticles has been developed. Selenium nanoparticles are characterized by a clear bimodal size distribution: 2-3 and ~37 nm. The main active centers of complexation with nanoparticles are the amino and hydroxyl groups of chitosan. In experiments on culturing fibroblasts of the hTERT BJ-5ta cell line on sample films, high biocompatibility of the composition was shown. It was shown that the composition of chitosan-selenium nanoparticles has a corrective effect on the oxidative processes of the body, reducing the activity of free-radical oxidation in the blood of animals. This opens up prospects for the use of this complex in the composition of antioxidant and adaptogenic drugs.

Keywords: antioxidant properties; biocompatibility; chitosan; nanocomposite; selenium nanoparticles.

© Pleiades Publishing, Inc. 2022, ISSN 0003-6838, Applied Biochemistry and Microbiology, 2022, Vol. 58, No. 2, pp. 126–131. © Pleiades Publishing, Inc., 2022.Russian Text © The Author(s), 2022, published in Prikladnaya Biokhimiya i Mikrobiologiya, 2022, Vol. 58, No. 2, pp. 140–145.