Targeting the Key Enzymes of Abnormal Fatty Acid β-oxidation as a Potential Strategy for Tumor Therapy

Hongdan Chen; Zeyu Yang; Yiceng Sun; Supeng Yin; Mi Tang; Fan Zhang

doi:10.31083/j.fbl2703095

Targeting the Key Enzymes of Abnormal Fatty Acid β-oxidation as a Potential Strategy for Tumor Therapy

Front Biosci (Landmark Ed). 2022 Mar 9;27(3):95. doi: 10.31083/j.fbl2703095.

Authors

Hongdan Chen¹, Zeyu Yang¹, Yiceng Sun¹, Supeng Yin¹, Mi Tang¹, Fan Zhang¹

Affiliation

¹ Department of Breast and Thyroid Surgery, Chongqing General Hospital, University of Chinese Academy of Sciences, 401147 Chongqing, China.

PMID: 35345327
DOI: 10.31083/j.fbl2703095

Abstract

Fatty acid metabolism has attracted extensive attention for its key role in the occurrence and development of tumors. Fatty acids not only participate in the biosynthesis of phospholipids in the membrane to overcome the demand for rapidly proliferating membrane lipids but also provide ATP, signaling molecules, and NADPH through β-oxidation to maintain tumor survival and growth. However, the specific role of fatty acid β-oxidation in tumors and the description of multiple potential targets in this process are not comprehensive and systematic. Therefore, this review summarizes the function of fatty acid β-oxidation in tumors and studies of key enzymes that catalyze related reactions in various stages to improve the overall understanding of fatty acid β-oxidation and search for novel tumor treatment strategies and ideas.

Keywords: ATP; NADPH; fatty acid β-oxidation; review; tumor.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Fatty Acids* / metabolism
Humans
Lipid Metabolism
Neoplasms* / drug therapy
Oxidation-Reduction
Phospholipids / metabolism

Substances

Fatty Acids
Phospholipids