Biological action at a distance: Correlated pattern formation in adjacent tessellation domains without communication

PLoS Comput Biol. 2022 Mar 28;18(3):e1009963. doi: 10.1371/journal.pcbi.1009963. eCollection 2022 Mar.

Abstract

Tessellations emerge in many natural systems, and the constituent domains often contain regular patterns, raising the intriguing possibility that pattern formation within adjacent domains might be correlated by the geometry, without the direct exchange of information between parts comprising either domain. We confirm this paradoxical effect, by simulating pattern formation via reaction-diffusion in domains whose boundary shapes tessellate, and showing that correlations between adjacent patterns are strong compared to controls that self-organize in domains with equivalent sizes but unrelated shapes. The effect holds in systems with linear and non-linear diffusive terms, and for boundary shapes derived from regular and irregular tessellations. Based on the prediction that correlations between adjacent patterns should be bimodally distributed, we develop methods for testing whether a given set of domain boundaries constrained pattern formation within those domains. We then confirm such a prediction by analysing the development of 'subbarrel' patterns, which are thought to emerge via reaction-diffusion, and whose enclosing borders form a Voronoi tessellation on the surface of the rodent somatosensory cortex. In more general terms, this result demonstrates how causal links can be established between the dynamical processes through which biological patterns emerge and the constraints that shape them.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Communication*
  • Diffusion
  • Somatosensory Cortex*

Grants and funding

This work was supported by a Collaborative Activity Award, Cortical Plasticity Within and Across Lifetimes, from the James S McDonnell Foundation (grant 220020516; https://www.jsmf.org/) to SPW. SPW and AJ-R are also supported by the EU Horizon 2020 programme through the FET Flagship Human Brain Project (HBP-SGA3, 945539). The funders played no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.