Actualities in Involvement of Estrogens in the Pathogenesis of Colorectal Cancer

R M Anghel; G L Serbanescu

doi:10.4183/aeb.2021.422

Actualities in Involvement of Estrogens in the Pathogenesis of Colorectal Cancer

Acta Endocrinol (Buchar). 2021 Jul-Sep;17(3):422-425. doi: 10.4183/aeb.2021.422.

Authors

R M Anghel^{1

2}, G L Serbanescu^{1

2}

Affiliations

¹ "Carol Davila" University of Medicine and Pharmacy, Faculty of General Medicine, Bucharest, Romania.
² Institute of Oncology, Bucharest, Romania.

Abstract

Gastrointestinal effects of estrogens are emerging as an important topic in colorectal cancer management. Current research demonstrated the link between inflammation and this malignancy, so important estrogen dependent mediators of the inflammatory response have been identified. Radioresistance and chemoresistance still represent an important cause of therapeutic failure in colorectal cancer and lead to further studies of colorectal carcinogenesis and predictive markers.

Keywords: Colorectal cancer; Estrogens; Pathogenesis.